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Identification and production of recombinant antigens for a vaccination against the screw-worm fly (Chrysomya bezziana)

Project ID

AS1/1992/003

Project Country

Commissioned Organisation

CSIRO Tropical Agriculture, Long Pocket Laboratories, Australia

Project Leader

Dr Peter Willadsen

Email

willad@dance.tap.csiro.au

Phone: 

07 32142778

Fax: 

07 3214 2884

Collaborating Institutions

Inter-University Centre on Biotechnology, Indonesia
Research Institute for Veterinary Science, Indonesia
Agency for Agricultural Research and Development, Indonesia
Queensland Department of Primary Industries, Australia

Project Budget

$867,593.00

Start Date

01/01/1995

Finish Date

31/12/1997

Extension Start Date

01/01/1998

Extension Finish Date

30/06/1999

ACIAR Research Program Manager

Dr John Copland

Overview Objectives

The aim of this project is to develop a vaccine to combat infestations of Screwworm Fly Chrysomya bezziana. The high cost of the insecticides and the problems of resistance, residues and their effects on non-target organisms have led to the search for cheaper more effective and environmentally safe control strategies.

Vaccinations as a control measure have proved effective against cattle tick. Considerable progress has been made in vaccinating sheep against sheep blow fly. Sheep vaccinated against sheep blow fly have also been shown to inhibit the growth of screwworm larvae.

Project Background and Objectives

Chrysomya bezziana, is a serious pest of buffalo, cattle, goats, sheep and pigs. Adult flies lay their eggs on wounds and undamaged skin. As the larvae develop they form deep wounds and within eight days they drop from the animal to pupate. The effect on the animal is loss of condition and appetite, anaemia, infertility, and death.

In Southeast Asia, some areas have 20-30% of cattle infested and 30% mortality in calves. On small farms screwworm infestations are frequently controlled by picking larvae out of the wounds and treating with tobacco, sump oil, petrol or battery acid.

On larger farms control is difficult, with treatment requiring the removal of larvae in conjunction with regular applications of insecticides which give little protection. Projected increases in stock numbers in the region and progression toward less intensive management of stock may mean greater losses due to screwworm.

Location

There are no project locations defined for this project.